Oh yeah! I don't have very many Spydercos but I love all 3 of mine. I agree about the ergonomics. My Para 3 seems like it would take a stick of dynamite to knock it out of my hand. The Persistence and Ambitious have great ergos too.
Spyderco is good stuff. I recommend trying one with the Compression lock. It's even more fun to use than Benchmade's Axis lock in my opinion.
I also have a small collection of Byrd Robins which are a Spyderco product. Like their parent brand, great ergonomics.